反应详情

温度

83 °C

Ethyl 3-amino-1H-pyrrole-2-carboxylate hydrochloride (3.00 g, 15.7 mmol) was dissolved in EtOH (40 mL). Formamidine acetic acid salt (2.44 g, 23.5 mmol) was added and the reaction mixture was heated under reflux at 83° C. for 18 h. The reaction mixture was cooled to r.t. and the precipitate was collected by filtration, washed with EtOH and dried in vacuo to give the title compound as a beige solid (1.70 g, 80%). LCMS (ES+): 135.9 (M+H)+.

1. temperaturethe reaction mixture was heated
2. temperatureThe reaction mixture was cooled to r.t.
3. filtrationthe precipitate was collected by filtration
4. washwashed with EtOH
5. customdried in vacuo