Azetidine → HCID 71537578, compound

HRID 588418Notes

Reaction equation

[NH:1]1[CH2:4][CH2:3][CH2:2]1.[CH3:5][N:6]1[C:10]([C:11](=[O:27])[NH:12][C:13]2[CH:14]=[CH:15][C:16]3[N:17]([N:19]=[C:20]([C:22]4[N:23]=[CH:24][S:25][CH:26]=4)[N:21]=3)[CH:18]=2)=[C:9]([C:28](O)=[O:29])[CH:8]=[N:7]1>>[N:1]1([C:28]([C:9]2[CH:8]=[N:7][N:6]([CH3:5])[C:10]=2[C:11]([NH:12][C:13]2[CH:14]=[CH:15][C:16]3[N:17]([N:19]=[C:20]([C:22]4[N:23]=[CH:24][S:25][CH:26]=4)[N:21]=3)[CH:18]=2)=[O:27])=[O:29])[CH2:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 10422Azetidine

HCID 89464206HCID 89464206, compound

Product 1

HCID 71537578HCID 71537578, compound

Procedure

Using azetidine and 1-methyl-5-(2-(thiazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid, the title compound was prepared in the same manner as described for example 2. Light brown solid (25 mg, 18%). MS: m/z=409.2 (M+H+).

Sources & evidence

ORD record: ord-776ad42f5a5f459d8567bae99acdc889
Source dataset: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09227970B2

Reaction notes

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