HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylcyclopropanamine → N4-Cyclopropyl-N4,1-dimethyl-N5-(2-(pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-pyrazole-4,5-dicarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylcyclopropanamine | HCID 11029756 | — |
| Reactant | 1-Methyl-5-(2-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid | HCID 89464524 | — |
| Product | N4-Cyclopropyl-N4,1-dimethyl-N5-(2-(pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-pyrazole-4,5-dicarboxamide | HCID 71538143 | — |
Reaction Steps
Using cyclopropyl-methyl-amine and 1-methyl-5-(2-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid, the title compound was prepared in the same manner as described for example 2. White solid (71 mg, 44%). Mp.: 237° C. MS: m/z=417.3 (M+H+). Ames test negative.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09227970B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-57a78f7b88cb4442abd09455b24eba89 |
| Source note | uspto-grants-2016_01 |