(6-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-dimethyl-amine → (2-Dimethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-carbamic acid tert-butyl ester

HRID 588441Notes

Reaction equation

HRID 588441 reaction equation
BrC1C=CC2N(N=C(N(C)C)N=2)C=1.[C:14]([O:18][C:19](=[O:36])[NH:20][C:21]1[CH:22]=[CH:23][C:24]2[N:25]([N:27]=[C:28]([N:30]3[CH2:35]COC[CH2:31]3)[N:29]=2)[CH:26]=1)([CH3:17])([CH3:16])[CH3:15]>>[C:14]([O:18][C:19](=[O:36])[NH:20][C:21]1[CH:22]=[CH:23][C:24]2[N:25]([N:27]=[C:28]([N:30]([CH3:31])[CH3:35])[N:29]=2)[CH:26]=1)([CH3:17])([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 89464315(6-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-dimethyl-amineHCID 89464434Tert-butyl 2-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamate

Product 1

HCID 89464594(2-Dimethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-carbamic acid tert-butyl ester

Procedure

Using (6-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-dimethyl-amine, this compound was prepared following the same method as for the synthesis of (2-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-carbamic acid tert-butyl ester. Reddish yellow solid (250 mg, 33%). MS: m/z=278 (M+H+).

Workup

  1. customthis compound was prepared

Sources & evidence

ORD record
ord-4e6dd002aa6d47028d39db456bbb1111
Source dataset
uspto-grants-2016_01
Patent number
US09227970B2

Reaction notes

Loading…