N*2*,N*2*-Diethyl-[1,2,4]triazolo[1,5-a]pyridine-2,6-diamine → 5-(2-Diethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

HRID 588452Notes

Reaction equation

HRID 588452 reaction equation
C(N(CC)C1N=C2C=CC(N)=CN2N=1)C.[CH2:16]([O:18][C:19]([C:21]1[CH:22]=[N:23][N:24]([CH3:44])[C:25]=1[C:26](=[O:43])[NH:27][C:28]1[CH:29]=[CH:30][C:31]2[N:32]([N:34]=[C:35]([N:37]3[CH2:42][CH2:41]O[CH2:39][CH2:38]3)[N:36]=2)[CH:33]=1)=[O:20])[CH3:17]>>[CH2:16]([O:18][C:19]([C:21]1[CH:22]=[N:23][N:24]([CH3:44])[C:25]=1[C:26](=[O:43])[NH:27][C:28]1[CH:29]=[CH:30][C:31]2[N:32]([N:34]=[C:35]([N:37]([CH2:42][CH3:41])[CH2:38][CH3:39])[N:36]=2)[CH:33]=1)=[O:20])[CH3:17]

Participants

3

Reactant 2

HCID 89464363N*2*,N*2*-Diethyl-[1,2,4]triazolo[1,5-a]pyridine-2,6-diamineHCID 894647211-methyl-5-(2-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid ethyl ester

Product 1

HCID 894636915-(2-Diethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

Procedure

Using N*2*,N*2*-diethyl-[1,2,4]triazolo[1,5-a]pyridine-2,6-diamine, this compound was prepared following the same method as for the synthesis of 1-methyl-5-(2-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid ethyl ester. Off white solid (1.2 g, 45%). MS: m/z=386 (M+H+).

Workup

  1. customthis compound was prepared

Sources & evidence

ORD record
ord-2bc158fb6ec04e4abc62eec51ad89611
Source dataset
uspto-grants-2016_01
Patent number
US09227970B2

Reaction notes

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