Morpholine → 2-Methyl-4-(morpholine-4-carbonyl)-2H-pyrazole-3-carboxylic acid (2-diethylamino-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-amide

HRID 588454Notes

Reaction equation

HRID 588454 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH2:7]([N:9]([CH2:31][CH3:32])[C:10]1[N:30]=[C:13]2[CH:14]=[CH:15][C:16]([NH:18][C:19]([C:21]3[N:25]([CH3:26])[N:24]=[CH:23][C:22]=3[C:27](O)=[O:28])=[O:20])=[CH:17][N:12]2[N:11]=1)[CH3:8]>>[CH2:31]([N:9]([CH2:7][CH3:8])[C:10]1[N:30]=[C:13]2[CH:14]=[CH:15][C:16]([NH:18][C:19]([C:21]3[N:25]([CH3:26])[N:24]=[CH:23][C:22]=3[C:27]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)=[O:28])=[O:20])=[CH:17][N:12]2[N:11]=1)[CH3:32]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 894634545-(2-Diethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Product 1

HCID 715386882-Methyl-4-(morpholine-4-carbonyl)-2H-pyrazole-3-carboxylic acid (2-diethylamino-[1,2,4]triazolo [1,5-a]pyridin-6-yl)-amide

Procedure

Using morpholine and 5-(2-diethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid, the title compound was prepared in the same manner as described for example 2. White solid (65 mg, 94%). MS: m/z=357 (M+H+).

Sources & evidence

ORD record
ord-cda81869e6844d75ab2cc96b5a57dec6
Source dataset
uspto-grants-2016_01
Patent number
US09227970B2

Reaction notes

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