2-Morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-6-amine → 2-(3-Methoxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-ylamine

HRID 588463Notes

Reaction equation

HRID 588463 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([N:8]=[C:9]([N:11]3[CH2:15][CH2:14][CH:13]([O:16][CH3:17])[CH2:12]3)[N:10]=2)[CH:7]=1.[N:18]1(C2N=C3C=CC(N)=CN3N=2)CCOCC1>>[CH3:17][O:16][CH:13]1[CH2:14][CH2:15][N:11]([C:9]2[N:10]=[C:5]3[CH:4]=[CH:3][C:2]([NH2:18])=[CH:7][N:6]3[N:8]=2)[CH2:12]1

Participants

3

Reactant 2

HCID 894644042-Morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-6-amineHCID 894645726-Bromo-2-(3-methoxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridine

Product 1

HCID 894637682-(3-Methoxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-ylamine

Procedure

Using 6-Bromo-2-(3-methoxy-pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridine, this compound was prepared following the same method as for the synthesis of 2-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylamine. Brown solid (1.4 g, 71%). MS: m/z=234 (M+H+).

Workup

  1. customthis compound was prepared

Sources & evidence

ORD record
ord-1fba53aa18e34c6788d99cc64d1c8918
Source dataset
uspto-grants-2016_01
Patent number
US09227970B2

Reaction notes

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