Tert-butyl trans-4-azido-3-fluoro-piperidine-1-carboxylate → tert-Butyl (3S,4S)-4-amino-3-fluoropiperidine-1-carboxylate

Participants

Reaction Steps

Palladium on carbon 10% (0.1 g) was added to a solution of tert-butyl (3S,4S)-4-azido-3-fluoropiperidine-1-carboxylate, 4.4 (0.4 g, 0.00163 mol) dissolved in EtOH (60 mL). The reaction was placed under a hydrogen atmosphere (40 psi pressure) for 16 h. The mixture was filtered through celite-bed and concentrated under reduced pressure to obtain the title compound tert-butyl (3S,4S)-4-amino-3-fluoropiperidine-1-carboxylate, 4.6 (0.4 g crude).

Provenance & Evidence