HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 588499Generated: October 25, 2026
Magnesium Carbonate → Tert-butyl 1-(5-formylthiazol-2-yl)ethylcarbamate
https://huagongshe.com/reaction/588499
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Magnesium Carbonate | HCID 11029 | — |
| Reactant | Chloromalonaldehyde | HCID 147646 | — |
| Reactant | tert-butyl N-[(1S)-1-carbamothioylethyl]carbamate | HCID 10932591 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Tert-butyl 1-(5-formylthiazol-2-yl)ethylcarbamate | HCID 86657335 | 71.5% |
Reaction Steps
A mixture of (S)-tert-butyl 1-amino-1-thioxopropan-2-ylcarbamate (6.9 g, 0.03 mol), 2-chloromalonaldehyde (5.2 g, 0.049 mol) and magnesium carbonate (2.76 g, 0.03 mol) in 1,4-dioxane (400 mL) was heated at 60° C. for 3 hours and further at room temperature overnight. The reaction mixture was concentrated and the residue purified by column chromatography (50-80% EtOAc/hexane) to afford tert-butyl 1-(5-formylthiazol-2-yl)ethylcarbamate (5.5 g, 64%). LC-MS: (FA) ES+ 257.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09227951B2 |
|---|
| Source dataset | uspto-grants-2016_01 |
|---|
| ORD ID | ord-f7575ef37cc1429288f17fcac56035ab |
|---|
| Source note | uspto-grants-2016_01 |
|---|
