HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-(1-Aminoethyl)thiophene-2-carboxylate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Methyl 2-(1-((tert-butoxycarbonyl)amino)ethyl)thiazole-5-carboxylate | HCID 67397774 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-(1-Aminoethyl)thiophene-2-carboxylate hydrochloride | HCID 67395343 | 100% |
Reaction Steps
To a solution of methyl 2-(1-(tert-butoxycarbonylamino)ethyl)thiazole-5-carboxylate (0.9 g, 3 mmol) in MeOH (5 mL) was added 4M HCl in dioxane (4 mL). The reaction was stirred overnight at room temperature. The reaction was evaporated to dryness to afford 5-(1-aminoethyl)thiophene-2-carboxylate hydrochloride (0.7 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09227951B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-c3649d2de7fc4711a31f99196f4546e7 |
| Source note | uspto-grants-2016_01 |