(S)-methyl 2-(benzyloxycarbonylamino)-3-(1H-indol-5-yl)propanoate → Methyl (S)-2-Amino-3-(5-indolyl)propanoate

Participants

Reaction Steps

To a solution of (S)-methyl 2-(benzyloxycarbonylamino)-3-(1H-indol-5-yl)propanoate (3.27 g, 9.39 mmol) in methanol (30 mL) was added Pd/C (10%, 200 mg). The mixture was stirred under hydrogen atmosphere at ambient temperature for 1 h and then filtered through a pad of Celite. The filtrate was concentrated to afford (S)-methyl 2-amino-3-(1H-indol-5-yl)propanoate (1.8 g, 88% yield) as a light green solid, which was used directly without further purification.

Provenance & Evidence