2-(Methylsulfonyl)ethanol → HCID 86717279, compound

HRID 588579Notes

Reaction equation

HRID 588579 reaction equation
[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]2[NH:14][N:15]=[C:16]([CH:17]3[CH2:19][CH2:18]3)[C:3]=12.[CH3:20][S:21]([CH2:24][CH2:25]O)(=[O:23])=[O:22]>>[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]2[N:14]([CH2:25][CH2:24][S:21]([CH3:20])(=[O:23])=[O:22])[N:15]=[C:16]([CH:17]3[CH2:19][CH2:18]3)[C:3]=12

Participants

3

Reactant 2

HCID 848342-(Methylsulfonyl)ethanolHCID 86717280HCID 86717280, compound

Product 1

HCID 86717279HCID 86717279, compound

Procedure

Compound Ix was synthesized from 4-chloro-3-cyclopropyl-5-phenyl-1H-pyrazolo[3,4-c]pyridazine and 2-(methylsulfonyl)ethanol following the general procedure for the Mitsunobu reaction as described above.

Workup

  1. customfor the Mitsunobu reaction

Sources & evidence

ORD record
ord-6b37e9a1310d4ae9839dc9cb2903d178
Source dataset
uspto-grants-2016_01
Patent number
US09227976B2

Reaction notes

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