反应详情

A solution of N-[4-(2-phenylethynyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]acetamide (900 mg, 3.07 mmol) in ethanol (12 mL) and 25% NaOH (9 mL) was heated to 70° C. for 1.5 h. The organic layer was separated and the aqueous extracted with EtOAc (×2). The combined organics were washed with water and the wash extracted with EtOAc. The combined organics were dried over MgSO4, filtered and evaporated, yielding the title compound as a red oil (652 mg) which was used in the subsequent step.

1. customThe organic layer was separated
2. extractionthe aqueous extracted with EtOAc (×2)
3. washThe combined organics were washed with water
4. extractionthe wash extracted with EtOAc
5. dry with materialThe combined organics were dried over MgSO4
6. filtrationfiltered
7. customevaporated