2-(Methylsulfonyl)ethanol → 4-Chloro-1-(2-methylsulfonylethyl)-3,5-diphenyl-pyrazolo[3,4-c]pyridazine

HRID 588612Notes

Reaction equation

HRID 588612 reaction equation
[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]2[NH:14][N:15]=[C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:3]=12.[CH3:23][S:24]([CH2:27][CH2:28]O)(=[O:26])=[O:25]>>[Cl:1][C:2]1[C:7]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)=[N:6][N:5]=[C:4]2[N:14]([CH2:28][CH2:27][S:24]([CH3:23])(=[O:26])=[O:25])[N:15]=[C:16]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[C:3]=12

Participants

3

Reactant 2

HCID 848342-(Methylsulfonyl)ethanolHCID 86697018CID 86697018

Product 1

HCID 867173094-Chloro-1-(2-methylsulfonylethyl)-3,5-diphenyl-pyrazolo[3,4-c]pyridazine

Procedure

Compound IIq was synthesized from 4-chloro-3,5-diphenyl-1H-pyrazolo[3,4-c]pyridazine and 2-(methylsulfonyl)ethanol following the general procedure for the Mitsunobu reaction as described above.

Workup

  1. customfor the Mitsunobu reaction

Sources & evidence

ORD record
ord-c733578f1ae640b1aee85cd100d75d3b
Source dataset
uspto-grants-2016_01
Patent number
US09227976B2

Reaction notes

Loading…