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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 588618Generated: October 30, 2026

1-(2-Hydroxyethyl)-2-pyrrolidinone → 1-[2-[4-Chloro-3-(3-fluorophenyl)-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl]ethyl]pyrrolidin-2-one

https://huagongshe.com/reaction/588618

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Hydroxyethyl)-2-pyrrolidinoneHCID 76980—
ReactantCID 86717314HCID 86717314—
Product1-[2-[4-Chloro-3-(3-fluorophenyl)-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl]ethyl]pyrrolidin-2-oneHCID 86717315—

Reaction Steps

Compound IIr was synthesized from 4-chloro-3-(3-fluorophenyl)-5-phenyl-1H-pyrazolo[3,4-c]pyridazine and 1-(2-hydroxyethyl)pyrrolidin-2-one following the general procedure for the Mitsunobu reaction as described.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09227976B2
Source datasetuspto-grants-2016_01
ORD IDord-d0d9d88f9a604576ac846198917f4aee
Source noteuspto-grants-2016_01