Iodine → HCID 178481731, compound

HRID 588631Notes

Reaction equation

HRID 588631 reaction equation
C1([I:7](OC(=O)C(F)(F)F)OC(=O)C(F)(F)F)C=CC=CC=1.[CH3:22][N:23]1[C:27]2[N:28]=[N:29][CH:30]=[C:31]([OH:32])[C:26]=2[C:25]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[N:24]1.II.N1C=CC=CC=1>C(Cl)Cl>[I:7][C:30]1[N:29]=[N:28][C:27]2[N:23]([CH3:22])[N:24]=[C:25]([C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=3)[C:26]=2[C:31]=1[OH:32]

Participants

6

Reactant 4

HCID 807IodineHCID 1049PyridineHCID 102317Bis(trifluoroacetoxy)iodobenzeneHCID 178481732HCID 178481732, compound

Product 1

HCID 178481731HCID 178481731, compoundYield 105.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Phenyl[bis(2,2,2-trifluoroacetoxy)]-λ3-iodane (190 mg, 0.43 mmol) was added to a suspension of 1-methyl-3-phenyl-pyrazolo[3,4-c]pyridazin-4-ol (166 mg, 0.73 mmol) in CH2Cl2 (3.7 mL), followed by the addition of iodine (111 mg, 0.43 mmol) and pyridine (71 μL). The reaction mixture was stirred at room temperature for 16 h, then filtered. The collected solid was washed with CH2Cl2 and dried, to yield the title compound (160 mg).

Workup

  1. filtrationfiltered
  2. washThe collected solid was washed with CH2Cl2
  3. customdried

Sources & evidence

ORD record
ord-97ce0c019645435e812694af312c2b2c
Source dataset
uspto-grants-2016_01
Patent number
US09227976B2

Reaction notes

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