Hydrochloric Acid → HCID 3738693, compound

Participants

Reaction Conditions

Reaction Steps

In a 50 mL round-bottomed flask, bromine (3 mL) was cooled to 0° C. and iron (0.56 g) was added. The mixture was stirred at 0° C. for 30 minutes. 3,5-dimethyladamantane-1-carboxylic acid (0.5 g) was added. The mixture was stirred at room temperature overnight. After adding ice and 6N aqueous HCl (10 mL), ethyl acetate (20 mL), and saturated aqueous Na2SO3 were added. The aqueous layer was extracted twice with ethyl acetate. The combined organic layers were washed with saturated Na2SO3 (50 mL, 3×) and dried over Na2SO4. After filtration and removal of the solvent, the product was used directly in the next step.

Provenance & Evidence