1H-Pyrazole, 4-chloro- → 1-(2-oxatricyclo[3.3.1.13,7]dec-1-ylmethyl)-4-chloro-1H-pyrazole

HRID 588683Notes

Reaction equation

HRID 588683 reaction equation
[C:1]12([CH2:11]O)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)C1)[CH2:8]2.[Cl:13][C:14]1[CH:15]=[N:16][NH:17][CH:18]=1.CC1C(B2OC(C)(C)C(C)(C)[O:26]2)=C(C)NN=1>>[C:1]12([CH2:11][N:16]3[CH:15]=[C:14]([Cl:13])[CH:18]=[N:17]3)[CH2:8][CH:7]3[CH2:6][CH:5]([CH2:4][CH:3]([CH2:9]3)[O:26]1)[CH2:10]2

Participants

4

Reactant 3

HCID 275241H-Pyrazole, 4-chloro-HCID 64556Tricyclo(3.3.1.1'3,7)dec-1-ylmethanolHCID 162177133,5-Dimethylpyrazole-4-boronic acid, pinacol ester

Product 1

HCID 866812691-(2-oxatricyclo[3.3.1.13,7]dec-1-ylmethyl)-4-chloro-1H-pyrazole

Procedure

The title compound was prepared by substituting EXAMPLE 13A for 1-adamantanemethanol and 4-chloro-1H-pyrazole for 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole in EXAMPLE 2A.

Sources & evidence

ORD record
ord-f2e8746d1c424c809524d14d294cd52e
Source dataset
uspto-grants-2016_01
Patent number
US09227963B2

Reaction notes

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