HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclooctylamine → N-Cyclooctyl-4-iodo-3-methylpyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclooctylamine | HCID 2903 | — |
| Reactant | 2-Fluoro-4-iodo-3-methylpyridine | HCID 11776298 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-Cyclooctyl-4-iodo-3-methylpyridin-2-amine | HCID 84819603 | — |
Reaction Steps
2-Fluoro-4-iodo-3-methylpyridine (700 mg) in cyclooctanamine (3.8 g) was heated at 130° C. overnight, cooled and diluted with dichloromethane. The resulting mixture was loaded onto a silica gel cartridge, eluting with 0-100% dichloromethane in hexanes to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09227963B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-cbf3a276a7554df2b1b0511ecb9b1118 |
| Source note | uspto-grants-2016_01 |