Hydrochloride methanol → N-(1-(Azetidin-3-yl)azetidin-3-yl)acrylamide hydrochloride

Participants

Reaction Steps

A mixture of tert-butyl 3-(3-(acrylamido)azetidin-1-yl)azetidine-1-carboxylate (300 mg, 1.07 mmol) in HCl-MeOH (30 mL, 86 mmol) was stirred at room temperature for 1 h. The mixture was concentrated in vacuo to afford the crude product (250 mg) which was used directly in the next step without further purification.

Provenance & Evidence