tert-Butyl 4-(2-acrylamidoethyl)piperidine-1-carboxylate → N-(2-(Piperidin-4-yl)ethyl)acrylamide

Participants

Reaction Steps

A mixture of tert-butyl 4-(2-acrylamidoethyl)piperidine-1-carboxylate (600 mg, 2.13 mmol) in HCl/MeOH (60 mL, 2.86 M) was stirred at room temperature for 1 h. The mixture was concentrated in vacuo to yield the crude product (550 mg) as a solid which was used directly in the next step without further purification.

Provenance & Evidence