HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Glycine, N-(4-chloro-5-iodo-2-methoxyphenyl)-, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Tert-butyl 2-(4-chloro-5-iodo-2-methoxyphenylamino)acetic acid | HCID 131734448 | — |
| Product | Glycine, N-(4-chloro-5-iodo-2-methoxyphenyl)-, methyl ester | HCID 117610930 | — |
Reaction Steps
A mixture of tert-butyl 2-(4-chloro-5-iodo-2-methoxyphenylamino)acetic acid (3.0 g, 8.7 mmol), SOCl2 (3 mL) in MeOH (20 mL) was stirred at reflux for 2 h. The mixture was concentrated in vacuo to yield the crude product (3.1 g) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09227978B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-e0059a0200564c369a12efd96f0e2640 |
| Source note | uspto-grants-2016_01 |