Hydrochloride methanol → HCID 131734449, compound

HRID 588820Notes

Reaction equation

HRID 588820 reaction equation
[C:1]([CH:4]1[CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6][N:5]1C(OC(C)(C)C)=O)(=[O:3])[NH2:2].[ClH:24].CO>>[ClH:24].[ClH:24].[NH:5]1[CH2:6][CH2:7][NH:8][CH2:9][CH:4]1[C:1]([NH2:2])=[O:3]

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 53487859HCID 53487859, compound

Product 1

HCID 131734449HCID 131734449, compoundYield 100%

Procedure

A mixture of di-tert-butyl 2-carbamoylpiperazine-1,4-dicarboxylate (7.5 g, 22.79 mmol), in HCl/MeOH (75 mL, 2.86; N) was stirred at room temperature for 16 h. The mixture was concentrated in vacuo to yield the product (4.58 g, 100% yield) as a yellow solid.

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-4fa1dd72a2d9484fb66245fa962de03d
Source dataset
uspto-grants-2016_01
Patent number
US09227978B2

Reaction notes

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