Hydrochloride methanol → 1-Acryloylpiperazine-2-carboxamide hydrochloride

HRID 588822Notes

Reaction equation

HRID 588822 reaction equation
[C:1]([N:5]1[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH:6]1[C:18](=[O:20])[NH2:19])(=[O:4])[CH:2]=[CH2:3].[ClH:21].CO>>[ClH:21].[C:1]([N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH:6]1[C:18]([NH2:19])=[O:20])(=[O:4])[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 90459747HCID 90459747, compound

Product 1

HCID 904602351-Acryloylpiperazine-2-carboxamide hydrochloride

Procedure

A mixture of tert-butyl 4-acryloyl-3-carbamoylpiperazine-1-carboxylate (200 mg, 0.706 mmol) in HCl/MeOH (20 mL, 2.86; N) was stirred at room temperature for 1 h. The mixture was concentrated in vacuo to yield the crude product (160 mg) as a yellow solid which was used directly in next step without further purification.

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-9ec57f490ee34d1dadcc108d18066567
Source dataset
uspto-grants-2016_01
Patent number
US09227978B2

Reaction notes

Loading…