HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-2-methoxy-5-(prop-1-en-2-yl)benzenamine → 4-Chloro-5-isopropyl-2-methoxybenzenamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-2-methoxy-5-(prop-1-en-2-yl)benzenamine | HCID 90459393 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Chloro-5-isopropyl-2-methoxybenzenamine | HCID 117607190 | 93% |
Reaction Steps
A mixture of 4-chloro-2-methoxy-5-(prop-1-en-2-yl)benzenamine (160 mg, 0.81 mmol), Raney-Ni (20 mg) in MeOH (5 mL) was stirred at RT under H2 (1 atm) atmosphere for 8 h. The mixture was filtered and the filtrate was concentrated in vacuo to afford the desired product (150 mg, 93% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09227978B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-4815e61dd847421d91c841ffe3f47465 |
| Source note | uspto-grants-2016_01 |