Potassium Carbonate → HCID 90459920, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of tert-butyl 3-(4-(2-(4-bromo-5-chloro-2-methoxyphenylamino)acetyl)piperazin-1-yl)azetidine-1-carboxylate (100 mg, 0.193 mmol), Pd(dppf)2Cl2 (29 mg, 0.04 mmol) and K2CO3 (55 mg, 0.386 mmol) in DMF (10 mL) at RT, Et2Zn (0.8 mL, 0.8 mmol, 1.0 M in hexane) was added. The resulting mixture was stirred at 80° C. for 16 h. The mixture was partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over Na2SO4 and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (dichloromethane/methanol=50:1) to afford the crude product (100 mg). ESI-MS m/z: 467.5[M+1]+.

Provenance & Evidence