Hydrochloride methanol → HCID 90460393, compound

HRID 588904Notes

Reaction equation

HRID 588904 reaction equation
[C:1]([N:5]1[CH2:8][CH:7]([N:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH:10]2[CH3:22])[CH2:6]1)(=[O:4])[CH:2]=[CH2:3].CO.[ClH:25]>>[ClH:25].[CH3:22][CH:10]1[CH2:11][NH:12][CH2:13][CH2:14][N:9]1[CH:7]1[CH2:8][N:5]([C:1](=[O:4])[CH:2]=[CH2:3])[CH2:6]1

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 90456204HCID 90456204, compound

Product 1

HCID 90460393HCID 90460393, compound

Procedure

The mixture of tert-butyl 4-(1-acryloylazetidin-3-yl)-3-methylpiperazine-1-carboxylate (62 mg, 0.199 mmol) in MeOH/HCl (20 mL, 2.9 M) was stirred at RT for 1 h. The mixture was concentrated in vacuo to afford the crude product (59 mg). The crude product was used directly in the next step without further purification.

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-32fc2094c85941cb9746023e07009e6c
Source dataset
uspto-grants-2016_01
Patent number
US09227978B2

Reaction notes

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