HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl 2-(4-hydroxypiperidin-1-yl)acetate → 2-(4-Hydroxypiperidin-1-yl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl 2-(4-hydroxypiperidin-1-yl)acetate | HCID 21805034 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(4-Hydroxypiperidin-1-yl)acetic acid | HCID 11205927 | 94.2% |
Reaction Steps
A mixture of benzyl 2-(4-hydroxypiperidin-1-yl)acetate (1.0 g, 4.0 mmol) and Pd/C (0.1 g) in methanol (20 mL) was hydrogenated for 1 h at ambient temperature. The Pd/C was filtered off and the filtrate was concentrated to dryness to afford 2-(4-hydroxypiperidin-1-yl)acetic acid (0.6 g, 94% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434761B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-0ee9a04ec4db4b5b8a636c014129ccd8 |
| Source note | uspto-grants-2016_09 |