Methanol → HCID 90013475, compound

Participants

Reaction Conditions

Reaction Steps

A stream of CO gas was bubbled through a mixture of methyl 2-(2-(2-bromopyridin-3-yl)-1-phenylethoxy)acetate (6.5 g, 18 mmol), sodium acetate (4.6 g, 55 mmol) and 1,1′-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex (3.0 g, 3.7 mmol) in anhydrous methanol (650 mL) at 70° C. for 4 h. The reaction mixture was cooled to 23° C. and concentrated. The residue was dissolved ethyl acetate (200 mL) and filtered through Celite®. The filtrate was concentrated and the residue was purified by flash chromatography on silica gel eluting with 40% ethyl acetate in petroleum ether to give the title compound. MS: m/z=330.2 (M+1).

Provenance & Evidence