Sodium Chloride → HCID 117992061, compound

Participants

Reaction Conditions

Reaction Steps

Sodium chloride (0.10 g, 1.7 mmol) was added to a solution of methyl 9-hydroxy-6-phenyl-5,6-dihydrooxepino[4,5-b]pyridine-8-carboxylate (0.50 g, 1.7 mmol) in dimethylsulfoxide (8 mL) and water (0.4 mL). The resulting mixture was heated at 150° C. for 2 h, then cooled and partitioned between water and ethyl acetate (3×). The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, and concentrated. The residue was purified by flash chromatography on silica gel eluting with 40% ethyl acetate in petroleum ether to give the title compound. MS: m/z=240.0 (M+1).

Provenance & Evidence