反应详情

温度

90 °C

Sodium tetrahydroborate (44 mg, 1.2 mmol) was added to a solution of 8-bromo-6-fluoro-3-pyridin-3-yl-2H-1,4-benzoxazin-5-amine (190 mg, 0.58 mmol) in ethanol (4 mL) and water (1 mL), and heated at 90° C. for 15 minutes. The mixture was concentrated, diluted with water, and extracted with ethyl acetate. The organic solvents were evaporated to afford the product. LCMS calc. for C13H12BrFN3O (M+H)+: m/z=324.0. found: 324.0.

1. concentrationThe mixture was concentrated
2. additiondiluted with water
3. extractionextracted with ethyl acetate
4. customThe organic solvents were evaporated
5. customto afford the product