Phosphorus oxychloride → HCID 90409257, compound

Participants

Reaction Conditions

Reaction Steps

Phosphoryl chloride (1.5 mL, 16 mmol) was added to a vial charged with 7-(3,5-dimethylisoxazol-4-yl)-9-fluoro-4-pyridin-3-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2(1H)-one (32 mg, 0.087 mmol) and the mixture was stirred overnight at 90° C. The mixture was quenched with ice-cold water, diluted with NaHCO3 and extracted with ethyl acetate. The organic extracts were collected and evaporated to afford the title compound. LCMS calc. for C19H15ClFN4O2 (M+H)+: m/z=385.1. found: 385.1.

Provenance & Evidence