Potassium Hydroxide → potassium (S)-2-(2-morpholinoacetamido)propanoate

Participants

Reaction Steps

Crude (S)-methyl 2-(2-morpholinoacetamido)propanoate was dissolved in methanol (10 mL) and KOH (20 mL of a 1N solution, 0.020 mmol). The reaction mixture was stirred for 3 h then concentrated, dissolved in methanol, and filtered. The filtrate was concentrated to provide potassium (S)-2-(2-morpholinoacetamido)propanoate (8.38 g, 92% over 2 steps) as a colorless oil. MS (EI) for C9H15KN2O4, found 217.2 [M−K]+.

Provenance & Evidence