Sodium Bicarbonate → HCID 67294907, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of compound tert-butyl 3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(methylthio)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate (319 mg, 0.4 mmol), Oxone (1.2 g, 2 mmol) and NaHCO3 (336 mg, 4 mmol) in MeOH (12 mL) and Water (3 mL) was heated at 65° C. for 15 h, at which time LC/MS analysis confirmed full consumption of starting material. After cooling, it was diluted with DCM: MeOH (1:1, 100 mL) and filtered. The filtrate was concentrated to afford the crude title product which was used for the next step without further purification.

Provenance & Evidence