Acetic Anhydride → HCID 178499167, compound

HRID 589164Notes

Reaction equation

HRID 589164 reaction equation
[NH2:1][C:2]1[NH:3][C:4]([C:7]([O:9][CH3:10])=[O:8])=[N:5][N:6]=1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>>[C:11]([NH:1][C:2]1[NH:3][C:4]([C:7]([O:9][CH3:10])=[O:8])=[N:5][N:6]=1)(=[O:13])[CH3:12]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 178499168HCID 178499168, compound

Product 1

HCID 178499167HCID 178499167, compound

Procedure

A suspension of methyl 5-amino-4H-1,2,4-triazole-3-carboxylate (1.42 g, 10.0 mmol) in acetic anhydride (30 mL) was refluxed for 30 min until a clear solution was formed. The solution was evaporated to dryness and H2O (40 mL) was added. The resulting suspension was stirred at rt overnight. H2O was evaporated to afford the titled compound as a white powder (1.85 g), which was used without further purification.

Workup

  1. temperaturewas refluxed for 30 min until a clear solution
  2. customwas formed
  3. customThe solution was evaporated to dryness and H2O (40 mL)
  4. additionwas added
  5. customH2O was evaporated

Sources & evidence

ORD record
ord-52ae599d28fc4cb79d8f9cd436610e29
Source dataset
uspto-grants-2016_01
Patent number
US09227971B2

Reaction notes

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