HCID 178469940, compound → HCID 178524806, compound

Participants

Reaction Steps

A solution of ethyl 3-hydroxy-1H-pyrazole-4-carboxylate (625 mg, 4.00 mmol) in 10% NaOH (aq) (20 mL) and EtOH (10 mL) was heated under reflux for 20 h. EtOH was removed under reduced pressure. The residue was diluted with 10 mL of H2O and acidified with 4 N HCl. The precipitates were filtered to afford the titled compound as a white solid (460 mg), which was used without further purification.

Provenance & Evidence