HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 2-Bromo-1-(5-bromopyridin-2-YL)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 1-(5-Bromopyridin-2-yl)ethan-1-one | HCID 23145345 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-Bromo-1-(5-bromopyridin-2-YL)ethanone | HCID 23624707 | — |
Reaction Steps
1-(5-bromopyridin-2-yl)ethanone (200 mg, 1.0 mmol) was dissolved in Acetic acid (50 mL) and HBr in Acetic acid (48% solution, 280 uL) was added along with water (100 uL). Warmed to 70 C and added Bromine (51.5 uL, 1.0 mmol) and stirred for 1 hour. The reaction was concentrated to give the desired product (280 mg) containing a small amount of dibrominated product. This material was used as is.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09227971B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-9e86130f31db484c83063b1007b90d27 |
| Source note | uspto-grants-2016_01 |