反应详情

温度

100 °C

A mixture of 6,7-dihydro-5H-cyclopenta[b]pyridine 1-oxide and acetic anhydride was stirred for 30 minutes at 100° C. Concentrated and added DCM (30 mL). The organic layer was washed with Sat. NaHCO3. The organic layer was dried over sodium sulfate and filtered. The organic layer was concentrated in vacuo and purification of the crude material via Isco (3-5% Methanol/DCM) gave rise to the desired 6,7-dihydro-5H-cyclopenta[b]pyridine-7-yl acetate (900 mg).

1. concentrationConcentrated
2. additionadded DCM (30 mL)
3. washThe organic layer was washed with Sat. NaHCO3
4. dry with materialThe organic layer was dried over sodium sulfate
5. filtrationfiltered
6. concentrationThe organic layer was concentrated in vacuo and purification of the crude material via Isco (3-5% Methanol/DCM)