Potassium Hydroxide → HCID 67295247, compound

HRID 589207Notes

Reaction equation

HRID 589207 reaction equation
[CH3:1][Si:2]([CH3:17])([CH3:16])[CH2:3][CH2:4][O:5][CH2:6][N:7]1[CH:11]=[N:10][N:9]=[C:8]1[C:12]([O:14]C)=[O:13].[OH-].[K+]>CCO>[CH3:1][Si:2]([CH3:17])([CH3:16])[CH2:3][CH2:4][O:5][CH2:6][N:7]1[CH:11]=[N:10][N:9]=[C:8]1[C:12]([OH:14])=[O:13]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 67295225HCID 67295225, compound

Product 1

HCID 67295247HCID 67295247, compoundYield 127.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of methyl 4-((2-(trimethylsilyl)ethoxy)methyl)-4H-1,2,4-triazole-3-carboxylate (225 mg, 0.874 mmol, 1.00 equiv) in EtOH (1.5 mL) was added aq. KOH (2N, 0.9 mL, 0.87 mmol, 1.0 equiv). After stirring at rt for 1 hr, the reaction mixture was concentrated affording the title compound as a colorless solid (271 mg) (Table 8-30).

Workup

  1. concentrationthe reaction mixture was concentrated

Sources & evidence

ORD record
ord-1675f9a01dd049b1b74b070d9743e6ca
Source dataset
uspto-grants-2016_01
Patent number
US09227971B2

Reaction notes

Loading…