反应详情

温度

70 °C

Anhydrous methanol (50 mL) is taken in a 100 mL 2-necked round bottom flask fitted with a reflux condenser and an additional dropping funnel and cooled to ice temperature. Acetyl chloride (3 mL) is added drop wise through the dropping funnel. After 15 min, D-phenylalanine (3 g, 18.16 mmol) is added and the reaction mixture is refluxed at 70° C. for overnight. The reaction mixture is vacuo dried to obtain D-phenylalanine methylester hydrochloride in quantitative yield and used for further reaction without purification.

1. customfitted with a reflux condenser and an additional dropping funnel
2. temperaturecooled to ice temperature
3. customdried