Sodium Carbonate → HCID 12034427, compound

Participants

Reaction Steps

First, a mixture of 5.00 g of 2,3-dichloropyrazine, 10.23 g of 3,5-dimethylphenylboronic acid, 7.19 g of sodium carbonate, 0.29 g of bis(triphenylphosphine)palladium(II) dichloride (PdCl2(PPh3)2), 20 mL of water, and 20 mL of acetonitrile was heated for 60 minutes under argon atmosphere while irradiated with microwaves (2.45 GHz, 100 W). Furthermore, 2.55 g of 3,5-dimethylphenylboronic acid, 1.80 g of sodium carbonate, 0.070 g of PdCl2(PPh3)2, 5 mL of water, and 5 mL of acetonitrile were added, and irradiation with microwaves (2.45 GHz, 100 W) was performed again for 60 minutes so that heating was performed. The mixture was added with water, subjected to extraction with dichloromethane, and purified by column chromatography (developing solvent: hexane:ethyl acetate=5:1 (v/v) and then dichloromethane:ethyl acetate=10:1 (v/v)) to give 2,3-bis(3,5-dimethylphenyl)pyrazine (Hdmdppr) as white powder in 44% yield.

Provenance & Evidence