Thionyl Chloride → HCID 86663089, compound

HRID 589296Notes

Reaction equation

HRID 589296 reaction equation
[Cl:1][C:2]1[N:6]([CH3:7])[N:5]=[C:4]([CH:8]([F:10])[F:9])[C:3]=1[C:11]([OH:13])=O.S(Cl)([Cl:16])=O>>[Cl:1][C:2]1[N:6]([CH3:7])[N:5]=[C:4]([CH:8]([F:10])[F:9])[C:3]=1[C:11]([Cl:16])=[O:13]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 197546935-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Product 1

HCID 86663089HCID 86663089, compound

Procedure

3.2 g of 5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid and 44.3 ml of thionyl chloride are refluxed for 5 hours. After cooling down, the reaction mixture is evaporated under vacuum to yield 3.5 g of 5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbonyl chloride as a yellow oil. 1H NMR (400 MHz, CHCl3-d6) δ ppm: 3.97 (s, 3H); 7.00 (t, J=52.01 Hz, 1 H); IR (TQ): 1759 and 1725 cm−1 (C═O).

Workup

  1. temperatureAfter cooling down
  2. customthe reaction mixture is evaporated under vacuum

Sources & evidence

ORD record
ord-da09788f2c154a98993ad002c0203a02
Source dataset
uspto-grants-2016_01
Patent number
US09232799B2

Reaction notes

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