Hydrogen Peroxide → 2-(3-Chloro-4-hydroxyphenylamino)-5-[(2-hydroxyethyl)methylamino][1,4]benzoquinone

Participants

Reaction Steps

To a solution of 0.90 g (0.005 mol) of 4-amino-2-chlorophenol hydrochloride in 5 ml of water and 2 ml of 20% aqueous ammonia is added a solution of 1.23 g (0.005 mol) of 4-methyl-3,4-dihydro-2H-1,4-benzoxazin-6-ol hydrobromide in 3 ml of water, 1 ml of 20% aqueous ammonia and 10 ml of acetone. The pH is adjusted to 9.5 with 20% aqueous ammonia. 17 ml of 6% aqueous hydrogen peroxide solution are added. After 3 hours, the precipitate is filtered off. 0.99 g of 2-(3-chloro-4-hydroxyphenylamino)-5-[(2-hydroxyethyl)methylamino][1,4]benzoquinone (compound 7) is obtained in the form of a brown powder.

Provenance & Evidence