反应详情

Into a dry reaction vessel, methyl 2-[2-methyl-1-(4-nitrobenzyl)-1H-indol-3-yl]acetate (300 mg, 0.887 mmol) was added, and dissolved in 10 mL methanol. 10% Pd/C 20 mg was added, and reacted under hydrogen for 3 hours. After completion of the reaction, it was filtered. The filter cake was washed with methanol, and the filtrate was rotate evaporated to dryness to obtain a solid 260 mg, at a yield of 95.0%.

1. additionwas added
2. customreacted under hydrogen for 3 hours
3. customAfter completion of the reaction, it
4. filtrationwas filtered
5. washThe filter cake was washed with methanol
6. customthe filtrate was rotate evaporated to dryness