Ethyl bromoacetate → ethyl 2-[3-(4-nitrobenzyl)-1H-indazol-1-yl]acetate

Participants

Reaction Steps

Into a dry reaction vessel, 2.15 g (8.49 mmol) 3-(4-nitrobenzyl)-1H-indazole, 10 mL DMF, 1.70 g (10.2 mmol) ethyl bromoacetate, 5.54 g (17.0 mmol) cesium carbonate were respectively added, and reacted at room temperature overnight. It was chromatographed on a column to obtain 1.4 g red solid, at a yield of 48.5%.

Provenance & Evidence