Hydrochloric Acid → HCID 178525250, compound

Participants

Reaction Conditions

Reaction Steps

3-Amino-3-(5-fluoro-2-nitrophenyl)propionic acid (15.32 g, 67.1 mmol) was dissolved in a mixed solution of 5% sodium hydroxide solution (80 mL) and 85% hydrazine hydrate (5 mL). The reaction was heated to 80° C., and then Raney nickel (2×25 mg) was added carefully. After reacted for half an hour, it was cooled, and adjusted to pH=2 with 6 N hydrochloric acid. A solid precipitated, pumping filtered, dried in vacuum to obtain a yellow solid 1.12 g, at a yield of 8.6%.

Provenance & Evidence