Cesium carbonate → HCID 89590293, compound

Participants

Reaction Steps

Ethyl 2-(6-fluoro-1H-indazol-3-yl)acetate (2.08 g, 9.36 mmol) was dissolved in anhydrous tetrahydrofuran (30 mL). Cesium carbonate (9.15 g, 28.1 mmol) was added, and stirred at room temperature for half an hour. Then p-nitro benzyl bromide (2.02 g, 9.35 mmol) was added, and reacted for 16 hours. Then the solid was filtered. The filtrate was concentrated, chromatographed on a silica gel column (petroleum ether:ethyl acetate=2:1) to obtain a yellow solid 1.38 g, at a yield of 41.2%.

Provenance & Evidence