反应详情

N-(5-methylpyridin-2-yl)-2-naphthamide (1.31 g, 5.0 mmol), N-bromosuccinimide (0.89 g, 5.0 mmol) and benzoyl peroxide (0.12 g, 0.5 mmol) were dissolved in carbon tetrachloride (50 mL), and reacted under protection of nitrogen for 16 hours. It was filtered while hot, and the filter cake was washed with carbon tetrachloride. The filtrate was concentrated, chromatographed on a silica gel column (petroleum ether:ethyl acetate=5:1) to obtain a white solid 0.66 g, at a yield of 38.6%.

1. customreacted under protection of nitrogen for 16 hours
2. filtrationIt was filtered while hot, and the filter cake
3. washwas washed with carbon tetrachloride
4. concentrationThe filtrate was concentrated
5. customchromatographed on a silica gel column (petroleum ether:ethyl acetate=5:1)