Lithium hydroxide, monohydrate → HCID 71571940, compound

Participants

Reaction Steps

Ethyl 2-[1-[[5-(2-naphthamido)pyrazin-2-yl]methyl]-1H-indazol-3-yl]acetate (0.466 g, 1.0 mmol) was dissolved in 20 mL tetrahydrofuran, and in an ice bath, was added 10 mL aqueous solution dissolving lithium hydroxide monohydrate (0.18 g, 4.3 mmol). It was reacted at room temperature for 3 h, rotate evaporated to dryness to remove the solvent, purified by preparative liquid phase (methanol:water=50%) to obtain a white solid 130 mg, at a yield of 29.7%.

Provenance & Evidence