Hydrochloric Acid → HCID 71572044, compound

Participants

Reaction Steps

Methyl 2-[1-[4-(N-methyl-2-naphthamido)benzyl]-1H-indazol-3-yl]acetate (about 1.0 mmol) was dissolved in tetrahydrofuran (30 mL), and in an ice bath, 20 mL aqueous solution dissolving lithium hydroxide monohydrate (210 mg, 5.0 mmol) was added. It was reacted at room temperature for 3 h, and the reaction was monitored to be complete by TLC. Water was added into the system, and adjusted to pH=3-4 with diluted hydrochloric acid. A solid precipitated, which was filtered, dried, and purified by preparative liquid phase to obtain a white solid 147 mg, at a total yield over two steps of 32.7%.

Provenance & Evidence